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Image Search Results
Journal: The Journal of Neuroscience
Article Title: Working Memory Impairment in Calcineurin Knock-out Mice Is Associated with Alterations in Synaptic Vesicle Cycling and Disruption of High-Frequency Synaptic and Network Activity in Prefrontal Cortex
doi: 10.1523/JNEUROSCI.5362-12.2013
Figure Lengend Snippet: Synaptic vesicle cycling proteins are hyperphosphorylated in CN-KO cortex. A, Western blotting was performed on cerebral cortex protein extracts from three control and three CN-KO mice. Protein was probed with antibodies against total and phosphorylated dynamin I (Dnm1), synapsin I (Syn1), and Pip5k1γ (Pip5k1c) at the indicated residues. Densitometry analysis was performed. B, Mean (±SEM) phospho:total band densitometry ratios, normalized to mean ratio of control bands. *p < 0.05. **p < 0.01. ***p < 0.001. ****p < 0.0001.
Article Snippet: A total of 20 μg of protein from nine samples (three samples from each group) was loaded onto each gel along with one lane of a
Techniques: Western Blot
Journal: The Journal of Neuroscience
Article Title: Working Memory Impairment in Calcineurin Knock-out Mice Is Associated with Alterations in Synaptic Vesicle Cycling and Disruption of High-Frequency Synaptic and Network Activity in Prefrontal Cortex
doi: 10.1523/JNEUROSCI.5362-12.2013
Figure Lengend Snippet: Levels of the synaptic vesicle cycling protein dynamin I are reduced in schizophrenia PFC. Western blotting was performed for dynamin I and β-III-tubulin on protein extracts generated from slices of PFC (Brodmann's area 46) from control individuals (n = 14) and from patients with schizophrenia (n = 11) or bipolar disease (n = 12). (See Table 1 for cohort information.) A, Representative Western blot showing dynamin I and β-III-tubulin expression from normal (N), schizophrenia (S), and bipolar (B) brain samples; C indicates a normalization control consisting of a commercial human cerebral cortex sample. B, Mean (±SEM) dynamin I protein levels measured and calculated as described in Materials and Methods. **p < 0.01.
Article Snippet: A total of 20 μg of protein from nine samples (three samples from each group) was loaded onto each gel along with one lane of a
Techniques: Western Blot, Generated, Expressing